XBI Holdings: Equity List and Weights
SPDR S&P Biotech ETF
157 positive-weight equity holdings in this dataset · State Street (SPDR) · holdings as of 2026-10-08
This list covers equity positions represented in the dataset. Cash, derivatives, options, structured notes, and other non-equity assets are excluded, so the listed weights may not sum to 100% and are not a complete inventory of every fund asset.
What does XBI actually hold?
XBI (SPDR S&P Biotech ETF) has 157 positive-weight equity holdings represented in this dataset as of 2026-10-08. The source type is issuer daily holdings file from State Street (SPDR). The three largest positions are Moderna Inc at 2.20%, Twist Bioscience Corp at 1.84%, and Natera Inc at 1.79% of the fund. The ten largest equity holdings together account for 16.9 percentage points of reported fund exposure. The largest sector exposure is Health Care at 12.7%. Among the 80 funds tracked here, XBI overlaps most with VTV, sharing 3.3% of weight by the smaller-of-the-two method. Anyone holding XBI next to another broad fund can own the same companies twice without seeing it, because a fund-level allocation says nothing about the stocks underneath. Every weight shown on this page is read from the source dataset dated 2026-10-08, not estimated or modelled by OverlapCheck.
Holdings source and freshness
- Issuer
- State Street (SPDR)
- Source type
- issuer daily holdings file (
issuer_daily) - Holdings as of
- Source status
ok- Source checked
- Filing date
- Not supplied in the dataset
- SEC accession
- Not supplied in the dataset
- Source link
- Not supplied in the dataset
All 157 represented equity positions are available on this page. The largest 157 are included in the initial HTML; search or load more to browse the rest in manageable chunks. The ten largest account for 16.9 percentage points of reported exposure in the issuer daily holdings file dated 2026-10-08.
XBI equity holdings
Showing the largest 157 of 157 positive-weight equity holdings in the initial HTML, ordered from highest to lowest reported weight. Search or load additional chunks to browse the complete list without leaving this page.
Showing 157 of 157 holdings.
| # | Company | Ticker | % of fund |
|---|---|---|---|
| 1 | Moderna Inc | MRNA | 2.20% |
| 2 | Twist Bioscience Corp | TWST | 1.84% |
| 3 | Natera Inc | NTRA | 1.79% |
| 4 | Abbvie Inc | ABBV | 1.65% |
| 5 | United Therapeutics Corp | UTHR | 1.59% |
| 6 | Amgen Inc | AMGN | 1.58% |
| 7 | Biogen Inc | BIIB | 1.57% |
| 8 | Halozyme Therapeutics Inc | HALO | 1.55% |
| 9 | Iovance Biotherapeutics Inc | IOVA | 1.54% |
| 10 | Exelixis Inc | EXEL | 1.53% |
| 11 | Gilead Sciences Inc | GILD | 1.53% |
| 12 | Tg Therapeutics Inc | TGTX | 1.48% |
| 13 | Vertex Pharmaceuticals Inc | VRTX | 1.46% |
| 14 | Protagonist Therapeutics Inc | PTGX | 1.46% |
| 15 | Krystal Biotech Inc | KRYS | 1.43% |
| 16 | Crispr Therapeutics Ag | CRSP | 1.41% |
| 17 | Ptc Therapeutics Inc | PTCT | 1.40% |
| 18 | Spyre Therapeutics Inc | SYRE | 1.39% |
| 19 | Regeneron Pharmaceuticals | REGN | 1.39% |
| 20 | Neurocrine Biosciences Inc | NBIX | 1.38% |
| 21 | Revolution Medicines Inc | RVMD | 1.37% |
| 22 | Incyte Corp | INCY | 1.36% |
| 23 | Alkermes Plc | ALKS | 1.34% |
| 24 | Grail Inc | GRAL | 1.33% |
| 25 | Erasca Inc | ERAS | 1.33% |
| 26 | Vaxcyte Inc | PCVX | 1.33% |
| 27 | Madrigal Pharmaceuticals Inc | MDGL | 1.32% |
| 28 | Alnylam Pharmaceuticals Inc | ALNY | 1.32% |
| 29 | Bridgebio Pharma Inc | BBIO | 1.30% |
| 30 | Biomarin Pharmaceutical Inc | BMRN | 1.29% |
| 31 | Oruka Therapeutics Inc | ORKA | 1.28% |
| 32 | Cytokinetics Inc | CYTK | 1.27% |
| 33 | Roivant Sciences Ltd | ROIV | 1.24% |
| 34 | Kodiak Sciences Inc | KOD | 1.24% |
| 35 | Cogent Biosciences Inc | COGT | 1.20% |
| 36 | Kymera Therapeutics Inc | KYMR | 1.20% |
| 37 | Travere Therapeutics Inc | TVTX | 1.19% |
| 38 | Immunitybio Inc | IBRX | 1.19% |
| 39 | Insmed Inc | INSM | 1.18% |
| 40 | Ionis Pharmaceuticals Inc | IONS | 1.17% |
| 41 | Dianthus Therapeutics Inc | DNTH | 1.17% |
| 42 | Praxis Precision Medicines I | PRAX | 1.16% |
| 43 | Arrowhead Pharmaceuticals In | ARWR | 1.11% |
| 44 | Rhythm Pharmaceuticals Inc | RYTM | 1.09% |
| 45 | Veracyte Inc | VCYT | 1.04% |
| 46 | Mirum Pharmaceuticals Inc | MIRM | 1.03% |
| 47 | Cg Oncology Inc | CGON | 1.00% |
| 48 | Viking Therapeutics Inc | VKTX | 0.98% |
| 49 | Tango Therapeutics Inc | TNGX | 0.94% |
| 50 | Relay Therapeutics Inc | RLAY | 0.87% |
| 51 | Beam Therapeutics Inc | BEAM | 0.87% |
| 52 | Caredx Inc | CDNA | 0.84% |
| 53 | Celcuity Inc | CELC | 0.83% |
| 54 | Ultragenyx Pharmaceutical In | RARE | 0.80% |
| 55 | Scholar Rock Holding Corp | SRRK | 0.79% |
| 56 | Arcutis Biotherapeutics Inc | ARQT | 0.76% |
| 57 | Dyne Therapeutics Inc | DYN | 0.73% |
| 58 | Hyperliquid Strategies | PURR | 0.69% |
| 59 | Recursion Pharmaceuticals A | RXRX | 0.67% |
| 60 | Sellas Life Sciences Group I | SLS | 0.65% |
| 61 | Immunovant Inc | IMVT | 0.65% |
| 62 | Summit Therapeutics Inc | SMMT | 0.64% |
| 63 | Ideaya Biosciences Inc | IDYA | 0.59% |
| 64 | Biocryst Pharmaceuticals Inc | BCRX | 0.59% |
| 65 | Denali Therapeutics Inc | DNLI | 0.59% |
| 66 | Vera Therapeutics Inc | VERA | 0.56% |
| 67 | Agios Pharmaceuticals Inc | AGIO | 0.56% |
| 68 | Intellia Therapeutics Inc | NTLA | 0.55% |
| 69 | Sarepta Therapeutics Inc | SRPT | 0.55% |
| 70 | Novavax Inc | NVAX | 0.52% |
| 71 | Arcus Biosciences Inc | RCUS | 0.51% |
| 72 | Nurix Therapeutics Inc | NRIX | 0.50% |
| 73 | Acadia Pharmaceuticals Inc | ACAD | 0.50% |
| 74 | Palvella Therapeutics Inc | PVLA | 0.49% |
| 75 | Celldex Therapeutics Inc | CLDX | 0.48% |
| 76 | Adma Biologics Inc | ADMA | 0.48% |
| 77 | Uniqure Nv | QURE | 0.47% |
| 78 | Viridian Therapeutics Inc | VRDN | 0.47% |
| 79 | Absci Corp | ABSI | 0.45% |
| 80 | Vericel Corp | VCEL | 0.45% |
| 81 | Biohaven Ltd | BHVN | 0.45% |
| 82 | Disc Medicine Inc | IRON | 0.45% |
| 83 | Precigen Inc | PGEN | 0.44% |
| 84 | Syndax Pharmaceuticals Inc | SNDX | 0.44% |
| 85 | Nektar Therapeutics | NKTR | 0.41% |
| 86 | Immunome Inc | IMNM | 0.39% |
| 87 | Mineralys Therapeutics Inc | MLYS | 0.34% |
| 88 | Replimune Group Inc | REPL | 0.33% |
| 89 | Xencor Inc | XNCR | 0.33% |
| 90 | Stoke Therapeutics Inc | STOK | 0.32% |
| 91 | Inhibrx Biosciences Inc | INBX | 0.31% |
| 92 | Anaptysbio Inc | ANAB | 0.30% |
| 93 | Oric Pharmaceuticals Inc | ORIC | 0.30% |
| 94 | Vir Biotechnology Inc | VIR | 0.29% |
| 95 | First Tracks Biotherapeu W/I | TRAX | 0.29% |
| 96 | Zenas Biopharma Inc | ZBIO | 0.28% |
| 97 | Kura Oncology Inc | KURA | 0.27% |
| 98 | Mannkind Corp | MNKD | 0.25% |
| 99 | Jade Biosciences Inc | JBIO | 0.25% |
| 100 | Ardelyx Inc | ARDX | 0.24% |
| 101 | Annexon Inc | ANNX | 0.24% |
| 102 | Rigel Pharmaceuticals Inc | RIGL | 0.24% |
| 103 | Tyra Biosciences Inc | TYRA | 0.24% |
| 104 | Taysha Gene Therapies Inc | TSHA | 0.23% |
| 105 | Geron Corp | GERN | 0.23% |
| 106 | Monte Rosa Therapeutics Inc | GLUE | 0.22% |
| 107 | Candel Therapeutics Inc | CADL | 0.22% |
| 108 | Janux Therapeutics Inc | JANX | 0.22% |
| 109 | Vor Biopharma Inc | VOR | 0.21% |
| 110 | Avalo Therapeutics Inc | AVTX | 0.20% |
| 111 | Immix Biopharma Inc | IMMX | 0.20% |
| 112 | Cullinan Therapeutics Inc | CGEM | 0.19% |
| 113 | Bicara Therapeutics Inc | BCAX | 0.19% |
| 114 | Corvus Pharmaceuticals Inc | CRVS | 0.19% |
| 115 | Verastem Inc | VSTM | 0.19% |
| 116 | Olema Pharmaceuticals Inc | OLMA | 0.17% |
| 117 | Regenxbio Inc | RGNX | 0.16% |
| 118 | Hemab Therapeutics Holdings | COAG | 0.16% |
| 119 | Savara Inc | SVRA | 0.16% |
| 120 | Arrivent Biopharma Inc | AVBP | 0.16% |
| 121 | Sana Biotechnology Inc | SANA | 0.16% |
| 122 | Achieve Life Sciences Inc | ACHV | 0.15% |
| 123 | 4D Molecular Therapeutics In | FDMT | 0.15% |
| 124 | Damora Therapeutics Inc | DMRA | 0.15% |
| 125 | Capricor Therapeutics Inc | CAPR | 0.15% |
| 126 | Allogene Therapeutics Inc | ALLO | 0.13% |
| 127 | Prime Medicine Inc | PRME | 0.13% |
| 128 | Ironwood Pharmaceuticals Inc | IRWD | 0.13% |
| 129 | Cytomx Therapeutics Inc | CTMX | 0.13% |
| 130 | Kailera Therapeutics Inc | KLRA | 0.13% |
| 131 | Editas Medicine Inc | EDIT | 0.12% |
| 132 | Solid Biosciences Inc | SLDB | 0.12% |
| 133 | Myriad Genetics Inc | MYGN | 0.12% |
| 134 | Climb Bio Inc | CLYM | 0.12% |
| 135 | Arbutus Biopharma Corp | ABUS | 0.12% |
| 136 | Altimmune Inc | ALT | 0.12% |
| 137 | Monopar Therapeutics Inc | MNPR | 0.12% |
| 138 | Sagimet Biosciences Inc A | SGMT | 0.12% |
| 139 | Emergent Biosolutions Inc | EBS | 0.11% |
| 140 | Design Therapeutics Inc | DSGN | 0.11% |
| 141 | Ocugen Inc | OCGN | 0.11% |
| 142 | Shattuck Labs Inc | STTK | 0.11% |
| 143 | Ars Pharmaceuticals Inc | SPRY | 0.10% |
| 144 | Cabaletta Bio Inc | CABA | 0.10% |
| 145 | Aktis Oncology Inc | AKTS | 0.09% |
| 146 | Mimedx Group Inc | MDXG | 0.09% |
| 147 | Vanda Pharmaceuticals Inc | VNDA | 0.08% |
| 148 | Prothena Corp Plc | PRTA | 0.08% |
| 149 | Neurogene Inc | NGNE | 0.07% |
| 150 | Assembly Biosciences Inc | ASMB | 0.07% |
| 151 | Ovid Therapeutics Inc | OVID | 0.07% |
| 152 | Aura Biosciences Inc | AURA | 0.06% |
| 153 | Faeth Therapeutics Inc | FTH | 0.06% |
| 154 | Lexeo Therapeutics Inc | LXEO | 0.05% |
| 155 | Compass Therapeutics Inc | CMPX | 0.05% |
| 156 | Crescent Biopharma Inc | CBIO | 0.05% |
| 157 | Bridgebio Oncology Therapeut | BBOT | 0.02% |
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Sector breakdown
Sectors assigned via S&P 500 sector-ETF membership; small-cap and international holdings appear as Unclassified. See methodology.
Overlaps most with
Lowest holdings overlap
These are the lowest holdings-overlap scores among the funds tracked here, not fund recommendations. Holdings overlap does not measure correlation, volatility, geographic or factor exposure, fees, or suitability.
XBI options dashboard
XBI has a liquid options market. Our sister site Quant Data computes max pain, put/call ratio, and open-interest walls for XBI nightly from end-of-day open interest.
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