XBI Holdings: Equity List and Weights
SPDR S&P Biotech ETF
147 positive-weight equity holdings in this dataset · State Street (SPDR) · holdings as of 2026-08-25
This list covers equity positions represented in the dataset. Cash, derivatives, options, structured notes, and other non-equity assets are excluded, so the listed weights may not sum to 100% and are not a complete inventory of every fund asset.
What does XBI actually hold?
XBI (SPDR S&P Biotech ETF) has 147 positive-weight equity holdings represented in this dataset as of 2026-08-25. The source type is issuer daily holdings file from State Street (SPDR). The three largest positions are Moderna Inc at 3.05%, Twist Bioscience Corp at 1.98%, and Apogee Therapeutics Inc at 1.44% of the fund. The ten largest equity holdings together account for 16.0 percentage points of reported fund exposure. The largest sector exposure is Health Care at 10.8%. Among the 80 funds tracked here, XBI overlaps most with QQQ, sharing 3.6% of weight by the smaller-of-the-two method. Anyone holding XBI next to another broad fund can own the same companies twice without seeing it, because a fund-level allocation says nothing about the stocks underneath. Every weight shown on this page is read from the source dataset dated 2026-08-25, not estimated or modelled by OverlapCheck.
Holdings source and freshness
- Issuer
- State Street (SPDR)
- Source type
- issuer daily holdings file (
issuer_daily) - Holdings as of
- Source status
ok- Source checked
- Filing date
- Not supplied in the dataset
- SEC accession
- Not supplied in the dataset
- Source link
- Not supplied in the dataset
All 147 represented equity positions are available on this page. The largest 147 are included in the initial HTML; search or load more to browse the rest in manageable chunks. The ten largest account for 16.0 percentage points of reported exposure in the issuer daily holdings file dated 2026-08-25.
XBI equity holdings
Showing the largest 147 of 147 positive-weight equity holdings in the initial HTML, ordered from highest to lowest reported weight. Search or load additional chunks to browse the complete list without leaving this page.
Showing 147 of 147 holdings.
| # | Company | Ticker | % of fund |
|---|---|---|---|
| 1 | Moderna Inc | MRNA | 3.05% |
| 2 | Twist Bioscience Corp | TWST | 1.98% |
| 3 | Apogee Therapeutics Inc | APGE | 1.44% |
| 4 | Kymera Therapeutics Inc | KYMR | 1.43% |
| 5 | Oruka Therapeutics Inc | ORKA | 1.41% |
| 6 | Natera Inc | NTRA | 1.38% |
| 7 | Halozyme Therapeutics Inc | HALO | 1.37% |
| 8 | Praxis Precision Medicines I | PRAX | 1.35% |
| 9 | Dianthus Therapeutics Inc | DNTH | 1.30% |
| 10 | Revolution Medicines Inc | RVMD | 1.30% |
| 11 | Cg Oncology Inc | CGON | 1.27% |
| 12 | Travere Therapeutics Inc | TVTX | 1.27% |
| 13 | Spyre Therapeutics Inc | SYRE | 1.26% |
| 14 | Protagonist Therapeutics Inc | PTGX | 1.26% |
| 15 | Regeneron Pharmaceuticals | REGN | 1.22% |
| 16 | Insmed Inc | INSM | 1.19% |
| 17 | Vaxcyte Inc | PCVX | 1.19% |
| 18 | Erasca Inc | ERAS | 1.17% |
| 19 | Rhythm Pharmaceuticals Inc | RYTM | 1.17% |
| 20 | Scholar Rock Holding Corp | SRRK | 1.17% |
| 21 | Amgen Inc | AMGN | 1.16% |
| 22 | Relay Therapeutics Inc | RLAY | 1.15% |
| 23 | Roivant Sciences Ltd | ROIV | 1.14% |
| 24 | Vertex Pharmaceuticals Inc | VRTX | 1.12% |
| 25 | Arrowhead Pharmaceuticals In | ARWR | 1.11% |
| 26 | Crispr Therapeutics Ag | CRSP | 1.09% |
| 27 | Viking Therapeutics Inc | VKTX | 1.09% |
| 28 | Incyte Corp | INCY | 1.09% |
| 29 | Iovance Biotherapeutics Inc | IOVA | 1.09% |
| 30 | Uniqure Nv | QURE | 1.09% |
| 31 | Sellas Life Sciences Group I | SLS | 1.08% |
| 32 | Gilead Sciences Inc | GILD | 1.08% |
| 33 | Acadia Pharmaceuticals Inc | ACAD | 1.08% |
| 34 | Bridgebio Pharma Inc | BBIO | 1.05% |
| 35 | Tg Therapeutics Inc | TGTX | 1.05% |
| 36 | Grail Inc | GRAL | 1.04% |
| 37 | Abbvie Inc | ABBV | 1.04% |
| 38 | Biomarin Pharmaceutical Inc | BMRN | 1.04% |
| 39 | Cogent Biosciences Inc | COGT | 1.04% |
| 40 | Cytokinetics Inc | CYTK | 1.02% |
| 41 | Krystal Biotech Inc | KRYS | 1.01% |
| 42 | Biogen Inc | BIIB | 1.00% |
| 43 | Immunovant Inc | IMVT | 1.00% |
| 44 | Alkermes Plc | ALKS | 0.99% |
| 45 | Dyne Therapeutics Inc | DYN | 0.97% |
| 46 | Madrigal Pharmaceuticals Inc | MDGL | 0.96% |
| 47 | Exelixis Inc | EXEL | 0.95% |
| 48 | Beam Therapeutics Inc | BEAM | 0.93% |
| 49 | Celcuity Inc | CELC | 0.92% |
| 50 | Mirum Pharmaceuticals Inc | MIRM | 0.92% |
| 51 | Immunitybio Inc | IBRX | 0.91% |
| 52 | Ptc Therapeutics Inc | PTCT | 0.88% |
| 53 | Summit Therapeutics Inc | SMMT | 0.88% |
| 54 | Ideaya Biosciences Inc | IDYA | 0.87% |
| 55 | Ultragenyx Pharmaceutical In | RARE | 0.86% |
| 56 | Neurocrine Biosciences Inc | NBIX | 0.84% |
| 57 | United Therapeutics Corp | UTHR | 0.84% |
| 58 | Viridian Therapeutics Inc | VRDN | 0.84% |
| 59 | Biocryst Pharmaceuticals Inc | BCRX | 0.84% |
| 60 | Vera Therapeutics Inc | VERA | 0.83% |
| 61 | Immunome Inc | IMNM | 0.78% |
| 62 | Denali Therapeutics Inc | DNLI | 0.77% |
| 63 | Ionis Pharmaceuticals Inc | IONS | 0.77% |
| 64 | Sarepta Therapeutics Inc | SRPT | 0.75% |
| 65 | Celldex Therapeutics Inc | CLDX | 0.74% |
| 66 | Alnylam Pharmaceuticals Inc | ALNY | 0.73% |
| 67 | Arcus Biosciences Inc | RCUS | 0.72% |
| 68 | Disc Medicine Inc | IRON | 0.70% |
| 69 | Recursion Pharmaceuticals A | RXRX | 0.70% |
| 70 | Intellia Therapeutics Inc | NTLA | 0.69% |
| 71 | Adma Biologics Inc | ADMA | 0.67% |
| 72 | Hyperliquid Strategies | PURR | 0.67% |
| 73 | Mineralys Therapeutics Inc | MLYS | 0.66% |
| 74 | Arcutis Biotherapeutics Inc | ARQT | 0.64% |
| 75 | Tango Therapeutics Inc | TNGX | 0.64% |
| 76 | Novavax Inc | NVAX | 0.63% |
| 77 | Syndax Pharmaceuticals Inc | SNDX | 0.62% |
| 78 | Agios Pharmaceuticals Inc | AGIO | 0.60% |
| 79 | Nurix Therapeutics Inc | NRIX | 0.59% |
| 80 | Veracyte Inc | VCYT | 0.58% |
| 81 | Palvella Therapeutics Inc | PVLA | 0.54% |
| 82 | Kodiak Sciences Inc | KOD | 0.52% |
| 83 | Caredx Inc | CDNA | 0.52% |
| 84 | Xencor Inc | XNCR | 0.51% |
| 85 | Cullinan Therapeutics Inc | CGEM | 0.49% |
| 86 | Biohaven Ltd | BHVN | 0.48% |
| 87 | Vir Biotechnology Inc | VIR | 0.47% |
| 88 | Stoke Therapeutics Inc | STOK | 0.47% |
| 89 | Vericel Corp | VCEL | 0.46% |
| 90 | Precigen Inc | PGEN | 0.46% |
| 91 | Absci Corp | ABSI | 0.44% |
| 92 | Inhibrx Biosciences Inc | INBX | 0.44% |
| 93 | Anaptysbio Inc | ANAB | 0.41% |
| 94 | Zenas Biopharma Inc | ZBIO | 0.41% |
| 95 | Oric Pharmaceuticals Inc | ORIC | 0.40% |
| 96 | Replimune Group Inc | REPL | 0.39% |
| 97 | Corvus Pharmaceuticals Inc | CRVS | 0.38% |
| 98 | Vor Biopharma Inc | VOR | 0.38% |
| 99 | First Tracks Biotherapeutics | TRAX | 0.37% |
| 100 | Kura Oncology Inc | KURA | 0.37% |
| 101 | Avalo Therapeutics Inc | AVTX | 0.36% |
| 102 | Tyra Biosciences Inc | TYRA | 0.33% |
| 103 | Janux Therapeutics Inc | JANX | 0.32% |
| 104 | Mannkind Corp | MNKD | 0.32% |
| 105 | Taysha Gene Therapies Inc | TSHA | 0.31% |
| 106 | Geron Corp | GERN | 0.30% |
| 107 | Jade Biosciences Inc | JBIO | 0.30% |
| 108 | Annexon Inc | ANNX | 0.29% |
| 109 | Monte Rosa Therapeutics Inc | GLUE | 0.27% |
| 110 | Immix Biopharma Inc | IMMX | 0.27% |
| 111 | Rigel Pharmaceuticals Inc | RIGL | 0.27% |
| 112 | Olema Pharmaceuticals Inc | OLMA | 0.26% |
| 113 | Sana Biotechnology Inc | SANA | 0.26% |
| 114 | Ardelyx Inc | ARDX | 0.25% |
| 115 | Candel Therapeutics Inc | CADL | 0.24% |
| 116 | Arrivent Biopharma Inc | AVBP | 0.24% |
| 117 | Bicara Therapeutics Inc | BCAX | 0.24% |
| 118 | Cytomx Therapeutics Inc | CTMX | 0.24% |
| 119 | Allogene Therapeutics Inc | ALLO | 0.23% |
| 120 | Altimmune Inc | ALT | 0.23% |
| 121 | Solid Biosciences Inc | SLDB | 0.23% |
| 122 | 4D Molecular Therapeutics In | FDMT | 0.23% |
| 123 | Ironwood Pharmaceuticals Inc | IRWD | 0.21% |
| 124 | Verastem Inc | VSTM | 0.21% |
| 125 | Damora Therapeutics Inc | DMRA | 0.19% |
| 126 | Ocugen Inc | OCGN | 0.17% |
| 127 | Prime Medicine Inc | PRME | 0.17% |
| 128 | Arbutus Biopharma Corp | ABUS | 0.17% |
| 129 | Capricor Therapeutics Inc | CAPR | 0.16% |
| 130 | Savara Inc | SVRA | 0.16% |
| 131 | Regenxbio Inc | RGNX | 0.16% |
| 132 | Compass Therapeutics Inc | CMPX | 0.15% |
| 133 | Cabaletta Bio Inc | CABA | 0.15% |
| 134 | Ovid Therapeutics Inc | OVID | 0.13% |
| 135 | Prothena Corp Plc | PRTA | 0.12% |
| 136 | Perspective Therapeutics Inc | CATX | 0.12% |
| 137 | Ars Pharmaceuticals Inc | SPRY | 0.12% |
| 138 | Mimedx Group Inc | MDXG | 0.11% |
| 139 | Lexeo Therapeutics Inc | LXEO | 0.11% |
| 140 | Vanda Pharmaceuticals Inc | VNDA | 0.11% |
| 141 | Achieve Life Sciences Inc | ACHV | 0.10% |
| 142 | Sagimet Biosciences Inc A | SGMT | 0.09% |
| 143 | Emergent Biosolutions Inc | EBS | 0.09% |
| 144 | Myriad Genetics Inc | MYGN | 0.09% |
| 145 | Bridgebio Oncology Therapeut | BBOT | 0.07% |
| 146 | Maplight Therapeutics Inc | MPLT | 0.06% |
| 147 | Sionna Therapeutics Inc | SION | 0.04% |
Hold XBI alongside other funds? The same stock can sit in several of them at once — see your true combined exposure →
Sector breakdown
Sectors assigned via S&P 500 sector-ETF membership; small-cap and international holdings appear as Unclassified. See methodology.
Overlaps most with
Lowest holdings overlap
These are the lowest holdings-overlap scores among the funds tracked here, not fund recommendations. Holdings overlap does not measure correlation, volatility, geographic or factor exposure, fees, or suitability.
XBI options dashboard
XBI has a liquid options market. Our sister site Quant Data computes max pain, put/call ratio, and open-interest walls for XBI nightly from end-of-day open interest.
→ See what XBI plus your other funds really hold, combined
Combining XBI with other funds is the stock-intersection view — the piece people miss most from the retired Morningstar Instant X-Ray. Here's our Morningstar Instant X-Ray alternative.